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Other Infections

West Nile Virus Outbreak May Be Largest Ever in U.S., Says CDC

Based on the number of cases so far this year, 2012 looks like it will have one of the worst outbreaks of mosquito-borne West Nile virus in the U.S. to date, Centers for Disease Control and Prevention (CDC) announced during a media telebriefing this week.alt

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FDA Approves Vaccines for Upcoming Flu Season, CDC Updates Recommendations

The U.S. Food and Drug Administration (FDA) last week announced approval of a new vaccine formulation for the 2012-2013 influenza season. In related news, the Centers for Disease Control and Prevention (CDC) issued revised flu vaccine guidelines, keeping in place the recommendation that all people age 6 months and older should receive a vaccine for the upcoming flu season. alt

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AIDS 2012: Novel PzMA Tuberculosis Combo Shows Potent Activity in Short-term Trial

A triple-combination regimen consisting of the experimental tuberculosis (TB) drug PA-824, the established TB drug pyrazinamide, and the widely used antibiotic moxifloxacin -- dubbed PaMZ -- showed potent bactericidal activity in a randomized 14-day study presented last week at the XIX International AIDS Conference (AIDS 2012) in Washington, DC, and published simultaneously in the July 23, 2012 issue of The Lancet.

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CDC Recommendation: Dual Treatment to Curb Tide of Drug-Resistant Gonorrhea

Increasing fears about the emergence of antibiotic resistant gonorrhea in the U.S. have prompted new treatment and surveillance recommendations from the Centers for Disease Control and Prevention (CDC). Gail Bolan, director of the agency's Division of STD Prevention, called the move "a critical pre-emptive strike to preserve the last effective treatment option." alt

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HPV Vaccine Provides Herd Immunity to Unvaccinated Women

The human papillomavirus (HPV) vaccine can offer protection to girls and young women who did not themselves undergo immunization, a phenomenon known as "herd immunity," according to a study published in the July 9, 2012, advance online edition of Pediatrics. Widespread immunity against high-risk altHPV types 16 and 18 may result in lower rates of cervical and anal cancer in years to come.

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AIDS 2012: Human Papillomavirus Doubles Risk of HIV infection

Pre-existing human papillomavirus (HPV) infection is associated with a 2-fold increase in the risk of HIV acquisition in women, and risk also rose for both heterosexual and gay/bisexual men, according to an 8-study review presented at the recent XIX International AIDS Conference (AIDS 2012) in Washington, DC, and published in the August 7, 2012, advance online edition of AIDS.alt

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H1N1 'Swine Flu' Deaths May Have Approached 300,000 Worldwide

The 2009 H1N1 influenza A epidemic may have caused approximately 284,500 deaths worldwide, about 15 times more than previously thought, according to a new estimates published in the June 26, 2012 advance online edition of Lancet Infectious Diseases.alt

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AIDS 2012: Isoniazid Preventive Therapy Reduces Risk of TB for HIV+ People on ART

Twelve months of isoniazid (INH) preventive therapy (IPT) significantly reduced the incidence of all tuberculosis (TB) diagnoses among HIV positive people who were taking concurrent antiretroviral therapy (ART) according to results of a large randomized study presented as a late-breaker at the recent XIX International AIDS Conference (AIDS 2012) in Washington, DC.

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Janssen Requests FDA Approval of Bedaquiline (TMC207) for Multidrug-resistant TB

Janssen Research & Development this week submitted a New Drug Application requesting U.S. Food and Drug Administration (FDA) accelerated approval of bedaquiline (formerly TMC207), which would be the first drug for difficult-to-treat multidrug-resistant tuberculosis (MDR-TB).

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