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Other Infections

Adding Delamanid to Combination Regimen Reduces Risk of Death for People with Resistant TB

The novel investigational tuberculosis (TB) drug delamanid, when added to an optimized combination regimen, significantly reduced mortality among patients with multidrug-resistant TB, according to a study published in the September 27, 2012, advance edition of the European Respiratory Journal.

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Retrovirus XMRV Not Linked to Chronic Fatigue or Prostate Cancer

An extensive analysis sponsored by the National Institute of Allergy and Infectious Diseases confirmed that xenotropic murine leukemia virus-related virus (XMRV) is not associated with chronic fatigue syndrome. A related study provided further evidence that XMRV is not linked to prostate cancer either and traced the sequence of events that led to that mistaken claim.  alt

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ICAAC 2012: Experimental Nitroimidazole TBA-354 Shows Promise against Tuberculosis in Early Studies

The experimental nitroimidazole TBA-354, under investigation by the TB Alliance, showed potent activity against Mycobacterium tuberculosis in vitro and in animal studies, according to a presentation this week at the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012) in San Francisco. alt

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WHO Issues New Coronavirus Alert, Says It Does Not Spread Easily Like SARS

The World Health Organization (WHO) last week issued an alert informing healthcare providers about a new coronavirus that has so far caused 1 known death due to respiratory illness and kidney failure. The agency issued an interim case definition and asked providers to be on the lookout for new cases.alt

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New Tick-borne Heartland Virus Identified in Missouri

Centers for Disease Control and Prevention (CDC) investigators have identified a new virus, thought to be transmitted by ticks, after 2 men in Missouri came down with an unexplained illness with fever and blood cell abnormalities, according to a report in the August 30, 2012, New England Journal of Medicine.

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ICAAC 2012: Are Statins Beneficial for Patients with Candida Fungal Infections?

Use of statin drugs to manage elevated cholesterol in people at risk for cardiovascular disease may also reduce short-term mortality among people with Candida fungal infections, perhaps due to their immunomodulatory properties,according to a study presented at the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012) this week in San Francisco.alt

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AIDS 2012: No Interactions Seen Between New TB Drug and Popular HIV Meds

The promising experimental tuberculosis (TB) drug delamanid does not interact with the widely used antiretrovirals tenofovir (Viread) and lopinavir/ritonavir (Kaletra) in ways likely to cause clinical problems, researchers reported at the XIX International AIDS Conference (AIDS 2012) last month in Washington, DC.

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Study Shows Extensively Drug-resistant TB is Becoming More Common Worldwide

More than 40% of people with multidrug-resistant pulmonary tuberculosis in a multi-country study were found to be resistant to at least 1 second-line anti-tuberculosis agent and 7% had extensively drug-resistant disease, researchers reported in the August 29, 2012, advance online edition of The Lancet.

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Immune Deficiency Cases in Asia May Be Due to Interferon-gamma Antibodies

Antibodies against interferon-gamma, a cytokine that plays an important role in immune defense against bacteria and viruses, were detected in nearly 90% of people in Taiwan and Thailand who developed multiple opportunistic infections (OIs), researchers reported in the August 23, 2012, New England Journal of Medicine.alt

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