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HIV/HCV Coinfection

EASL 2010: HIV/HCV Coinfected Patients with Acute Hepatitis C Are Equally Likely to Achieve Sustained Response with Interferon plus Ribavirin

Details: Category: Acute Hepatitis C; Published on Friday, 07 May 2010 12:56; Written by Liz Highleyman

HIV positive people with acute hepatitis C treated with pegylated interferon plus ribavirin, and HIV negative people treated with pegylated interferon alone, had a similar likelihood of achieving rapid virological response (RVR) at week 4 and sustained virological response (SVR) after completing treatment, according to findings presented at the 45th Annual Meeting of the European Association for the Study of the Liver (EASL 2010) last month in Vienna. RVR was the best predictor of SVR, but HIV/HCV coinfected patients had larger HCV viral load reductions between weeks 4 and 12, suggesting that ribavirin promotes "third phase" viral decline.

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EASL 2010: HIV and Hepatitis C Virus Coinfection May Increase Death of CD4 T-cells

Details: Category: HIV/HCV Coinfection; Published on Tuesday, 04 May 2010 12:56; Written by Liz Highleyman

Dual infection with HIV and hepatitis C virus (HCV) may promote heightened apoptosis, or programmed death, of CD4 T-cells, according to a poster presented last month at the 45th Annual Meeting of the European Association for the Study of the Liver (EASL 2010) in Vienna. This may help explain the finding in some studies that HIV/HCV coinfected people tend to experience more rapid HIV disease progression and have smaller CD4 cell gains on antiretroviral therapy (ART) than those with HIV alone.

Does Liver Fibrosis Progress Faster in People Who Have HIV When They Acquire Hepatitis C?

Details: Category: HIV/HCV Coinfection; Published on Friday, 19 February 2010 12:57; Written by Liz Highleyman

HIV positive men who subsequently became infected with hepatitis C virus (HCV) appeared to have a suspiciously rapid rate of liver disease progression in the European NEAT study, according to a poster presented at the 17th Conference on Retroviruses & Opportunistic Infections (CROI 2010) this week in San Francisco. The researchers suggested that apparent fast progression might be attributable to short duration of follow-up.

EASL 2010: Child-Pugh Score Changes Do Not Predict Liver Failure among HIV/HCV Coinfected Patients during Hepatitis C Treatment

Details: Category: HIV/HCV Coinfection; Published on Tuesday, 27 April 2010 12:55; Written by Liz Highleyman

Changes in Child-Pugh score, a clinical measure used to indicate the level of liver damage and risk of hepatic decompensation, may not reliably predict liver failure in HIV positive people with chronic hepatitis C virus (HCV) coinfection, since changes in the component parameters may be due to other causes, according to a poster presented at the 45th Annual Meeting of the European Association for the Study of the Liver (EASL 2010) this month in Vienna.

HIV/HCV Coinfected Veterans Have Elevated Risk of Chronic Kidney Disease

Details: Category: HIV/HCV Coinfection; Published on Tuesday, 09 February 2010 12:46; Written by Liz Highleyman

HIV positive people coinfected with hepatitis C virus (HCV) are more likely to have chronic kidney disease than individuals with HIV alone, and kidney disease is linked to significantly greater risk of death, according to a study of U.S. veterans described in the February 2010 Journal of Acquired Immune Deficiency Syndromes.

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EASL 2010: Biopsy Study Suggests Liver Disease Does Not Progress Faster in HIV/HCV Coinfected People

Details: Category: HIV/HCV Coinfection; Published on Tuesday, 20 April 2010 12:55; Written by Liz Highleyman

A poster presented last week at the 45th Annual Meeting of the European Association for the Study of the Liver (EASL 2010) in Vienna suggests that HIV/HCV coinfection may not significantly accelerate liver fibrosis progression compared with HCV alone. This biopsy study adds to a conflicting body of evidence about the impact of HIV on hepatitis C pathogenesis.

Elevated ALT Liver Enzymes in HIV Patients without Hepatitis B or C Are Linked to High Viral Load, Obesity, Alcohol, and Some NRTIs

Details: Category: HIV/HBV Coinfection; Published on Tuesday, 26 January 2010 13:15; Written by Liz Highleyman

Among HIV positive individuals without coexisting hepatitis C virus (HCV) or hepatitis B virus (HBV) infection, the incidence of persistent elevated ALT levels was 3.9 cases per 100 person-years, researchers reported in the February 15, 2010 issue of Clinical Infectious Diseases. The risk of ALT elevation was greater in people with high HIV RNA levels, higher body mass index (BMI), heavy alcohol use, and prolonged use of stavudine (d4T; Zerit) or zidovudine (AZT; Retrovir).

CROI 2010: HIV/HCV Coinfected Patients Demonstrate Poorer Neurocognitive Performance, but No Difference in Neural Imaging

Details: Category: Neurocognitive Problems; Published on Tuesday, 06 April 2010 13:57; Written by Liz Highleyman

HIV/HCV coinfected individuals with good HIV suppression on performed more poorly than HIV monoinfected people on neurocognitive tests, but the 2 groups showed no significant differences in neural imaging measures, according to a study presented at the recent 17th Conference on Retroviruses and Opportunistic Infections in San Francisco (CROI 2010).

Liver Transplant Do Not Impair Immune Response in HIV/HCV Coinfected Patients

Details: Category: Liver Transplant - HCV; Published on Friday, 15 January 2010 12:46; Written by Liz Highleyman

HIV/HCV coinfected patients who undergo liver transplantation do not lose immune responses to hepatitis C virus (HCV), HIV, or opportunistic infections, according to an analysis reported in the December 2009 Journal of Hepatology. This study adds to the evidence that appropriately selected coinfected individuals can be suitable candidates for liver transplants.

HIV/HCV Coinfection Fell along with Injection Drug Use among Men in HOPS; WIHS Women Appear Prone to HCV Sexual Transmission

Details: Category: HIV/HCV Coinfection; Published on Friday, 26 March 2010 12:46; Written by Liz Highleyman

Two recently published studies looked at the epidemiology of HIV/HCV coinfection in large, long-term cohort studies. Among men in the HIV Outpatient Study (HOPS), the HIV/HCV coinfection rate declined between 1996 and 2007, corresponding to a drop in the proportion of new HIV infections attributable to injection drug use. In the Women's Interagency HIV Study (WIHS), however, a considerable number of women who acquired hepatitis C virus (HCV) did not inject drugs but had partners who did, suggesting that sexual transmission occurs more often than previously assumed.

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Larger Viral Decline during Hepatitis C Treatment in HIV/HCV Coinfected People with Favorable IL28B Pattern

Details: Category: HIV/HCV Coinfection; Published on Monday, 11 January 2010 12:30; Written by Liz Highleyman

HIV/HCV coinfected patients with the C/C IL28B gene pattern experience larger decreases in hepatitis C virus (HCV) levels during the first phase of viral decline after starting treatment with pegylated interferon plus ribavirin, and were more likely to achieve virological response, researchers reported in the December 19, 2010 advance online edition of the Journal of Acquired Immune Deficiency Syndromes. A similar effect was seen for second-phase viral decline in people with HCV genotype 1, but not genotype 3.

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CROI 2010: HIV/HBV and HIV/HCV Coinfected People with Impaired Liver Function and Inflammation Have Higher Risk of Non-AIDS Death

Details: Category: HIV/HCV Coinfection; Published on Friday, 12 March 2010 12:57; Written by Liz Highleyman

HIV positive study participants with hepatitis B virus (HBV) or hepatitis C virus (HCV) coinfection who had higher blood levels of biomarkers associated with impaired liver function and inflammation were more likely to die of non-AIDS-related causes, researchers with the SMART treatment interruption trial reported last month at the 17th Conference on Retroviruses and Opportunistic Infections (CROI 2010) in San Francisco.

Factors that Influence the Decision of HIV/HCV Coinfected Patients to Start Treatment for Hepatitis C

Details: Category: HIV/HCV Coinfection; Published on Tuesday, 15 December 2009 12:49; Written by Liz Highleyman

It is estimated that nearly 30% of HIV positive people are coinfected with hepatitis C virus (HCV), and liver disease is a leading cause of death in this population. However, only a small number of HIV/HCV coinfected patients receive treatment for hepatitis C due to a variety of factors, according to an article published in the November 22, 2009 online edition of AIDS Patient Care and STDS.

CROI 2010: HIV Infection and HIV/HCV Coinfection Increased Risk of Strokes in Veterans Study

Details: Category: Cardiovascular Disease; Published on Friday, 05 March 2010 12:57; Written by Liz Highleyman

HIV positive veterans had about twice the risk of having a stroke as their HIV negative counterparts, and being coinfected with hepatitis C virus (HCV) further elevated the risk, but hepatitis C alone conferred an insignificant increase, according to a poster presented at the 17th Conference on Retroviruses & Opportunistic Infections (CROI 2010) last month in San Francisco. The researchers suggested stroke death may have been underestimated in the past.

Sustained Response to Pegylated Interferon plus Ribavirin in HIV/HCV Coinfected Patients with Advanced Immune Suppression

Details: Category: HIV/HCV Coinfection; Published on Tuesday, 01 December 2009 12:49; Written by Liz Highleyman

HIV/HCV coinfected individuals with advanced immune suppression are about as likely to achieved sustained virological response to interferon-based treatment as coinfected patients with better preserved immune function, but response rates are lower than those for HIV negative chronic hepatitis C patients, according to a report in the October 15, 2009 issue of Clinical Infectious Diseases

CROI 2010: More Evidence of Rapid Liver Disease Progression in HIV/HCV Coinfected People, but Antiretroviral Therapy Lowers Risk

Details: Category: HIV/HCV Coinfection; Published on Tuesday, 02 March 2010 12:57; Written by l

A study from Spain adds to the evidence that liver fibrosis due to hepatitis C virus (HCV) infection may progress unusually fast in people with HIV. However, the investigators reported at the 17th Conference on Retroviruses and Opportunistic Infections (CROI 2010) last month in San Francisco, effective antiretroviral therapy (ART) that suppresses HIV and raises CD4 cell count reduces the risk of liver disease progression.

Meta-analysis Shows Hepatitis C Virus Coinfection Does Not Lead to HIV Disease Progression

Details: Category: HIV/HCV Coinfection; Published on Tuesday, 17 November 2009 12:49; Written by Liz Highleyman

Coinfection with hepatitis C virus (HCV) is associated with higher mortality among HIV positive individuals in the highly active antiretroviral therapy (HAART) era, but this is not due to an increased risk of progression to AIDS-defining events, according to a meta-analysis described in the November 15, 2009 issue of Clinical Infectious Diseases.

CROI 2010: Moderate Liver Fibrosis Predicts Disease and Death in HIV/HCV Coinfected People, but Successful Treatment Appears Protective

Details: Category: Fibrosis & Cirrhosis; Published on Friday, 26 February 2010 19:16; Written by Liz Highleyman

Even moderate liver fibrosis (greater than stage F1) in HIV/HCV coinfected patients is associated with adverse clinical outcomes including liver cancer, liver failure, and death, investigators reported at the 17th Conference on Retroviruses & Opportunistic Infections (CROI 2010) last week in San Francisco. However, effective HIV treatment producing long-term viral suppression and successful hepatitis C treatment leading to sustained virological response appeared to be protective.

AASLD 2009: Study Looks at Factors Affecting Survival of HIV/HCV Coinfected Liver Transplant Recipients

Details: Category: Liver Transplant - HCV; Published on Friday, 13 November 2009 12:46; Written by Liz Highleyman

While HIV/HCV coinfected patients can have good outcomes after liver transplantation, acute organ rejection remains a risk factor and survival does not match that of HIV negative people with hepatitis C virus (HCV) alone, according to a study presented at the 60th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD 2009) this month in Boston.

CROI 2010: Leakage of Gut Bacteria Linked to Poor Hepatitis C Treatment Response in HIV/HCV Coinfected Patients

Details: Category: HIV/HCV Coinfection; Published on Friday, 26 February 2010 12:57; Written by Liz Highleyman

HIV/HCV coinfected individuals who did not respond well to interferon-based therapy for hepatitis C showed evidence of greater microbial translocation -- leakage of bacteria due to HIV damaging the gut -- than early responders, although T-cell activation did not differ, according to a poster presentation at the 17th Conference on Retroviruses & Opportunistic Infections (CROI 2010) last week in San Francisco.

Rapid Liver Fibrosis Progression and Successful Treatment of Acute Infection Suggest Benefits of Routine HCV Screening for HIV Positive Men

Details: Category: Acute Hepatitis C; Published on Tuesday, 10 November 2009 12:46; Written by Liz Highleyman

Researchers from Mt. Sinai School of Medicine presented data last week at the 60th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) in Boston that further characterize a cohort of HIV positive men with apparently sexually transmitted acute hepatitis C virus (HCV) infection. This group continues to experience more rapid than expected liver fibrosis progression. Hepatitis C treatment has been highly successful if started during the acute phase, but less so thereafter. The researchers recommended routine ALT and HCV antibody testing to allow for prompt treatment and to prevent liver disease progression. alt

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