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HIV/HCV Coinfection

Sexual Transmission of Hepatitis C among HIV Positive Men in the U.S. and Australia

Details: Category: HCV Sexual Transmission; Published on Friday, 25 February 2011 03:56; Written by Liz Highleyman

Nearly three-quarters of new hepatitis C virus (HCV) infections among HIV positive gay and bisexual men in the U.S. are likely due to sexual transmission, according to an analysis described in the January 31, 2011 advance online issue of Clinical Infectious Diseases. An Australian study published in the same issue found that sexual transmission accounted for a majority of cases among men who have sex with men, but injection drug use also played a role. These findings suggest that HIV positive people who have risky sex should undergo regular hepatitis C testing.

ICAAC 2011: HCV Drug Telaprevir Shows No Problematic Interactions with Raltegravir

Details: Category: HIV/HCV Coinfection; Published on Tuesday, 04 January 2011 00:00; Written by Liz Highleyman

The new hepatitis C virus (HCV) protease inhibitor telaprevir (Incivek) does not appear to have clinically relevant drug-drug interactions with the HIV integrase inhibitor raltegravir (Isentress), according to a study presented at the 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2011) last month in Chicago. alt

AIDS 2010: HIV/HCV Coinfected People with Normal Liver Enzymes Respond Well to Interferon-based Therapy

Details: Category: HIV/HCV Coinfection; Published on Tuesday, 10 August 2010 12:56; Written by Liz Highleyman

HIV positive people with normal levels of the liver enzyme alanine aminotransferase (ALT) who received hepatitis C therapy using pegylated interferon plus ribavirin responded as well as individuals with elevated ALT, according to findings presented at the XVIII International AIDS Conference (AIDS 2010) last month in Vienna.

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Tailored Treatment Duration Beneficial for HIV/HCV Coinfected Patients

Details: Category: HIV/HCV Coinfection; Published on Tuesday, 30 November 2010 12:48; Written by Liz Highleyman

Extending treatment with pegyalted interferon plus ribavirin for an extra 3 months raises the odds that HIV/HCV genotype 1 or 4 coinfected people will achieve sustained virological response, or a cure for hepatitis C, according to a Spanish study presented at the recent American Association for the Study of Liver Diseases "Liver Meeting" (AASLD 2010) in Boston. Patients with easier-to-treat HCV genotypes 2 or 3, however, did well with 6 months of treatment if they experienced rapid virological response.

HIV/HCV Coinfection, but Not HIV Alone, Raises Risk of Liver-related Death

Details: Category: HIV/AIDS Epidemiology & Mortality; Published on Tuesday, 03 August 2010 01:20; Written by Liz Highleyman

HIV positive people coinfected with hepatitis C virus (HCV) had an elevated mortality rate compared with the general population in Spain, but this was not the case for individuals with HIV alone, according to a study presented at the XVIII International AIDS Conference (AIDS 2010) last month in Vienna.

Rapid Liver Disease Progression among HIV Positive Men with Acute Hepatitis C Coinfection

Details: Category: HIV/HCV Coinfection; Published on Tuesday, 09 November 2010 12:48; Written by Liz Highleyman

People who already have HIV when they become infected with hepatitis C virus (HCV) may experience very rapid liver disease progression, researchers from Mt. Sinai Medical Center reported at the American Association for the Study of Liver Diseases "Liver Meeting" (AASLD 2010) held recently in Boston. A detailed review of 4 coinfected patients with persistent HCV viral load revealed progression to decompensated cirrhosis over relatively short periods of time, resulting in persistent symptoms, liver transplantation, or liver-related death. alt

AIDS 2010: Does Nevirapine Improve Response to Interferon-based Therapy in HIV/HCV Coinfected Patients?

Details: Category: HIV/HCV Coinfection; Published on Tuesday, 27 July 2010 13:56; Written by Liz Highleyman

Use of an antiretroviral therapy (ART) regimen containing nevirapine (Viramune) was associated with a higher rate of sustained virological response (SVR) to interferon-based therapy among HIV/HCV coinfected patients, according to a study presented last week at the XVIII International AIDS Conference (AIDS 2010) in Vienna. Researchers suggested that nevirapine may improve treatment response by reducing hepatitis C virus (HCV) viral load, but an alternative explanation may be that people taking nevirapine are in better health when starting hepatitis C treatment.

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Danish Study Looks at Hepatitis C Sexual Transmission among HIV Positive Gay Men

Details: Category: HCV Sexual Transmission; Published on Friday, 05 November 2010 12:48; Written by Liz Highleyman

Less than 1% of HIV positive gay and bisexual men seen at a Danish hospital were found to have acute hepatitis C virus (HCV) infection, according to a study presented at the American Association for the Study of Liver Diseases "Liver Meeting" (AASLD 2010) this week in Boston. All those who started hepatitis C treatment within 6 months of becoming infected achieved rapid virological response, while 1 who started later experienced HCV relapse.

National Viral Hepatitis Roundtable Applauds National AIDS Strategy's Recognition of HIV/HCV Coinfection

Details: Category: HIV/HBV Coinfection; Published on Tuesday, 20 July 2010 12:46; Written by NVHR

The National Viral Hepatitis Roundtable (NVHR) praised the inclusion of hepatitis B and C coinfection in the White House Office of National AIDS Policy's National HIV/AIDS Strategy released last week, given that an about 30% of HIV positive people also have HCV and approximately 10% also have HBV. The advocates also expressed hope that the administration will take a similar comprehensive approach to hepatitis B and C monoinfection, the latter of which affects about 4 times as many people as HIV.

HIV/HCV Coinfected Women More Likely than Men to Modify or Discontinue Hepatitis C Treatment

Details: Category: HIV/HCV Coinfection; Published on Friday, 22 October 2010 21:45; Written by Liz Highleyman

HIV positive women with chronic hepatitis C virus (HCV) coinfection experienced side effects of interferon-based therapy that were similar to those of coinfected men, but women developed these side effects sooner and were more likely to discontinue anti-HCV therapy or lower their doses for this reason, according to a study described in the October 1, 2010 Journal of Acquired Immune Deficiency Syndromes. Researchers also found that use of specific antiretroviral drugs can help predict adverse events during hepatitis C treatment.

HIV/HCV Coinfected People with Insulin Resistance Do Not Respond as Well to Interferon-based Therapy

Details: Category: HIV/HCV Coinfection; Published on Tuesday, 13 July 2010 00:41; Written by Liz Highleyman

After controlling for other risk factors, insulin resistance was an independent predictor of poor response to interferon plus ribavirin combination therapy for chronic hepatitis C in people with HIV, according to a Spanish study published in the June 23, 2010 Journal of Acquired Immune Deficiency Syndromes. The researchers suggested that management of insulin resistance may enhance response rates in the HIV/HCV coinfected population.

HIV Coinfection Does Not Worsen Liver Transplant Outcomes in People with Hepatitis B or C

Details: Category: Decompensation & ESLD; Published on Friday, 08 October 2010 12:46; Written by Liz Highleyman

HIV positive liver transplant recipients with hepatitis B virus (HBV) or hepatitis C virus (HCV) coinfection did not fare worse overall than HIV negative people, according to a Spanish study presented at the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2010) last month in Boston. Coinfected patients were less likely to experience organ rejection, but HCV recurrence was a leading cause of adverse outcomes.

Liver Steatosis in People with HIV/HCV Coinfection

Details: Category: HIV/HCV Coinfection; Published on Friday, 09 July 2010 12:46; Written by Liz Highleyman

HIV positive people with chronic hepatitis C virus (HCV) coinfected do not appear more likely to have hepatic steatosis, or fat accumulation in liver cells, than HIV positive individuals, according to a meta-analysis reported in the July 2010 issue of Hepatology. The analysis also saw no association with any class of antiretroviral drugs.

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Does CD4 Cell Count Influence Liver Fibrosis in HIV/HCV Coinfected People?

Details: Category: HCV Disease Progression; Published on Friday, 01 October 2010 12:46; Written by Liz Highleyman

Neither current nor lowest-ever CD4 T-cell levels were associated with hepatitis C virus (HCV) viral load or severity of liver fibrosis in HIV positive people after adjusting for other factors, according to a Spanish study presented at the recent 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2010) in Boston.

Reappearance of HCV in Gay Men Is Usually Due to Re-infection, Not Late Relapse

Details: Category: HCV Sexual Transmission; Published on Tuesday, 06 July 2010 00:28; Written by Liz Highleyman

Re-emergence of hepatitis C virus (HCV) in gay and bisexual men who were previously treated and achieved sustained virological response with interferon-based therapy appears to be due to reinfection, not late relapse occurring after the usual window for determining a cure, according to a genetic sequencing study described in the April 1, 2010 Journal of Acquired Immune Deficiency Syndromes.

Torque Teno Viruses More Common among HIV/HCV Coinfected People, Linked to Greater Liver Inflammation and Fibrosis

Details: Category: HIV/HCV Coinfection; Published on Tuesday, 21 September 2010 13:46; Written by Liz Highleyman

A common but little known set of viruses -- torque teno virus (TTV) and torque teno mini virus (TTMV) -- occur more often in HIV/HCV coinfected individuals than in healthy blood donors, and have been linked to worse liver inflammation and fibrosis progression, according to a poster presented at the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2010) last week in Boston.

HIV/HCV Coinfection Does Not Impair Virological or Immunological Response to Antiretroviral Therapy

Details: Category: HIV/HCV Coinfection; Published on Tuesday, 15 June 2010 12:46; Written by Liz Highleyman

HIV positive patients coinfected with hepatitis C virus (HCV) achieved HIV viral load suppression and CD4 cell recovery on antiretroviral therapy similar to that of people with HIV alone, according to a study from China described in the June 1, 2010 Journal of Acquired Immune Deficiency Syndromes. Coinfected individuals with detectable HCV antibodies and HCV RNA, however, appeared more likely to experience certain antiretroviral side effects.

End-of-Treatment Response to Interferon-based Therapy Reduces Liver Failure and Death in HIV/HCV Coinfected Patients

Details: Category: HIV/HCV Coinfection; Published on Tuesday, 21 September 2010 12:46; Written by Liz Highleyman

HIV/HCV coinfected individuals who experience an end-of-treatment response to interferon-based therapy for chronic hepatitis C virus (HCV) infection had a greatly reduced risk of liver decompensation and liver-related death, even if they did not go on to achieve sustained virological response, according to a Spanish study presented at the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2010) last week in Boston.

Screening for Liver Cancer in HIV/HCV Coinfected People

Details: Category: Liver Cancer/HCC; Published on Friday, 28 May 2010 23:40; Written by Liz Highleyman

Nearly half of HIV/HCV coinfected individuals with liver cancer in an international study were never screened for hepatocellular carcinoma, but those who did undergo screening had their cancer detected at an earlier stage, leading to more effective treatment and improved survival, according to a report presented at the 45th Annual Meeting of the European Association for the Study of the Liver (EASL 2010) last month in Vienna.

Worse Fibrosis Predicts Death in HIV/HCV Coinfected Individuals, Interferon Therapy Lowers Risk

Details: Category: HIV/HCV Coinfection; Published on Tuesday, 21 September 2010 09:17; Written by Liz Highleyman

HIV/HCV coinfected individuals with more advanced fibrosis have shorter survival than those with less liver damage, but treatment with interferon-based therapy reduces mortality risk, according to findings from a Spanish study presented at the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2010) recently held in Boston.

EASL 2010: Pegylated Interferon plus Ribavirin Works as Well in HIV/HCV Coinfected Patients with Cirrhosis

Details: Category: HIV/HCV Coinfection; Published on Friday, 28 May 2010 12:56; Written by Liz Highleyman

HIV/HCV coinfected patients with cirrhosis who received standard chronic hepatitis C therapy using pegylated interferon plus ribavirin had a sustained virological response rate similar to that of non-cirrhotic coinfected patients, according to research presented at the 45th Annual Meeting of the European Association for the Study of the Liver (EASL 2010) last month in Vienna.

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