Hepatitis C
Viral Load, HIV Status, but not IL28B Predict Perinatal HCV Transmission
- Details
- Category: Pregnancy & HCV MTCT
- Published on Friday, 29 April 2011 00:03
Women with higher HCV viral load and those coinfected with HIV were more likely to transmit HCV to their babies in a recent Spanish study. IL28B gene pattern did not affect transmission directly, but babies with the favorable CC pattern more often spontaneously cleared HCV.
BI 201335 for Hepatitis C Moves into Phase 3 Trials
- Details
- Category: Experimental HCV Drugs
- Published on Thursday, 28 April 2011 17:58
Boehringer Ingelheim this week announced that enrollment has begun for a Phase 3 clinical trial of its experimental HCV NS3/4A protease inhibitor BI 201335.
FDA Hearings Next Week on Boceprevir and Telaprevir for HCV
- Details
- Category: Experimental HCV Drugs
- Published on Saturday, 23 April 2011 00:18
FDA Antiviral Drugs Advisory Committee will hear evidence for boceprevir on April 27 and telaprevir on April 28.
EASL 2011: Boosted ABT-450 Improves Early Response to Interferon for Hepatitis C
- Details
- Category: Experimental HCV Drugs
- Published on Monday, 25 April 2011 23:54
Addition of the experimental HCV protease inhibitor ABT-450, boosted with ritonavir, to standard therapy increased the likelihood of complete early virological response at 12 weeks in previously untreated genotype 1 chronic hepatitis C patients.
Boosted Danoprevir Improves Response in Prior Null Responders
- Details
- Category: Experimental HCV Drugs
- Published on Tuesday, 19 April 2011 08:09
Nearly 90% of genotype 1b prior non-responder hepatitis C patients treated with ritonavir-boosted danoprevir plus pegylated interferon/ribavirin experienced early virological response at week 12, but breakthrough reached 50% for those with genotype 1a. 
Idera Delays Study of TLR9 Agonist IMO-2125 for Hepatitis C
- Details
- Category: Experimental HCV Drugs
- Published on Monday, 25 April 2011 23:43
Idera Pharmaceuticals has decided to hold off on a planned clinical trial of its experimental hepatitis C drug IMO-2125, pending further toxicity data from ongoing animal studies.
EASL 2011: Monoclonal Antibody Bavituximab Well-Tolerated by HIV/HCV Coinfected People
- Details
- Category: Experimental HCV Drugs
- Published on Friday, 15 April 2011 14:37
An experimental monoclonal antibody that inhibits HCV replication was safe and well-tolerated in a clinical trial of HIV positive people coinfected with chronic hepatitis C, researchers reported at EASL 2011.
EASL 2011: Tegobuvir Works Well in Triple and Quad Regimens for HCV
- Details
- Category: Experimental HCV Drugs
- Published on Saturday, 23 April 2011 13:56
Gilead's HCV polymerase inhibitor tegobuvir (GS-9190) improved response rates in treatment-naive genotype 1 patients when used in various combinations with pegylated interferon, ribavirin, and the experimental protease inhibitor GS-9256, researchers reported at EASL 2011.
EASL 2011: Pegylated Interferon Lambda Boosts Response with Few Side Effects
- Details
- Category: Experimental HCV Drugs
- Published on Friday, 15 April 2011 06:54
Hepatitis C patients taking an experimental interferon formulation -- pegylated interferon lambda -- had higher rates of rapid and early virological response, with fewer flu-like symptoms and blood cell deficiencies, according to a report at EASL 2011.
More Articles...
- EASL 2011: Once-Daily BI 201335 Ups Response to Interferon for Hepatitis C
- EASL 2011: BMS-790052 + Pegylated Interferon/Ribavirin Works Well for First HCV Treatment
- EASL 2011: BMS-790052/BMS-650032 Combo Cures Hepatitis C without Interferon
- EASL 2011: First Sustained Response Data for HCV Polymerase Inhibitor Mericitabine
- EASL 2011: Polymerase Inhibitor PSI-7977 Works with Interferon or Companion Drug
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