Hepatitis B
FDA Rejects Heplisav Hepatitis B Vaccine Seeking More Safety Data
- Details
- Category: HBV Vaccines
- Published on Thursday, 28 February 2013 00:00
- Written by Liz Highleyman
The U.S. Food and Drug Administration (FDA) has declined to approve Dynavax Technologies' experimental hepatitis B virus (HBV) vaccine candidate with a toll-like receptor 9 adjuvant, stating it wants to see further data on safety in adults including seniors, the company announced this week.
Antioxidant N-acetylcysteine Improves Survival of Transplanted Liver
- Details
- Category: HBV Treatment
- Published on Thursday, 28 February 2013 00:00
- Written by Liz Highleyman
N-acetylcysteine (NAC) administered during recovery of a liver from a deceased donor can help reduce damage during transplantation and increase survival of the liver graft in the recipient, according to a study published in the February 19, 2013, issue of Liver Transplantation.
Heavy Alcohol Use Increases Liver Cancer Risk for People with Hepatitis B
- Details
- Category: HBV Disease Progression
- Published on Thursday, 24 January 2013 00:00
- Written by Liz Highleyman
Hepatitis B patients with liver cirrhosis who consumed large amounts of alcohol were more likely to develop hepatocellular carcinoma (HCC) than people who drank less, according to a report in the December 6, 2012, online edition of the Journal of Hepatology. However, antiviral treatment can help prevent liver cancer.
Everolimus (Zortress) Approved to Prevent Liver Transplant Rejection
- Details
- Category: Liver Transplant - HBV
- Published on Wednesday, 20 February 2013 00:00
- Written by Novartis
The U.S. Food and Drug Administration (FDA) this month approved the immunosuppressant drug everolimus (brand name Zortress) for preventing organ rejection in people who undergo liver transplantation. A recent large study found that everolimus was easier on the kidneys when used in combination with low-dose tacrolimus (Prograf).
Liver Disease Is Leading Cause of Death for People with Chronic Hepatitis B
- Details
- Category: HBV Disease Progression
- Published on Tuesday, 15 January 2013 00:00
- Written by Liz Highleyman
Advanced liver disease caused by hepatitis B virus (HBV) -- including hepatocellular carcinoma (HCC) and decompensated cirrhosis -- accounted for more than 40% of deaths of people with chronic hepatitis B in a large health maintenance organization, researchers reported in the December 12, 2012, advance online edition of Hepatology.
HIV+ Less Likely to Respond to Hepatitis B Vaccine, but More Shots Increase Protection
- Details
- Category: HBV Prevention
- Published on Friday, 15 February 2013 00:00
- Written by Liz Highleyman
Adults in Kenya responded as well overall to hepatitis B vaccination as people in high-income countries. People with HIV had poorer response, but this could be mostly overcome with repeated doses, according to a study described in the February 1, 2013, Journal of Infectious Diseases.
Teens Vaccinated Against Hepatitis B as Infants May Lose Immunity
- Details
- Category: HBV Prevention
- Published on Friday, 11 January 2013 00:00
- Written by NIH
Adolescents who received combined active-passive hepatitis B virus (HBV) immunization soon after birth may lose "immunological memory" that protects them from future infection, with the HBeAg status of the mother playing a key role, researchers reported in the January 2013 issue of Hepatology.
Chronic Hepatitis Cohort Study Sheds Light on Burden of Hepatitis B and C in U.S.
- Details
- Category: HBV Epidemiology & Mortality
- Published on Friday, 01 February 2013 00:00
- Written by Liz Highleyman
People born between 1945 and 1964 account for the highest proportion of hepatitis B and C cases, and these viruses are a significant cause of illness and death, according to an analysis described in the January 1, 2013, Clinical Infectious Diseases.
Researchers Discover Structure of Hepatitis B Antigen that Interferes with Immune Response
- Details
- Category: HBV Basic Science
- Published on Tuesday, 08 January 2013 00:00
- Written by NIH
Researchers from the University of Oxford and the U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases have determined the crystal structure of the hepatitis B "e" antigen (HBeAg), which plays a role in immune tolerance and chronic hepatitis B virus (HBV) infection, according to a study published in the January 8, 2013, issue of the journal Structure. These findings may aid the development of new therapies that improve immune response against the virus.
More Articles...
- Most Hepatitis B Patients Who Respond to Tenofovir Show Improved Liver Health at 5 Years
- FDA Committee Says Heplisav Hepatitis B Vaccine Is Effective, but Safety Data Inadequate
- AASLD 2012: Entecavir Shows Good Efficacy for Black and Hispanic Hepatitis B Patients
- AASLD 2012: Adding Pegylated Interferon to Entecavir Improves HBV Treatment Response
- AASLD 2012: Patients with Cirrhosis Can Respond Well to Boceprevir or Telaprevir with Careful Monitoring
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