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AASLD Liver Meeting Starts Today in Boston

SUMMARY: The 60th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) -- better known as "The Liver Meeting" -- gets underway Friday, October 30, and will run through November 1 at the Hynes Convention Center in Boston. Treatments for hepatitis B and C will feature prominently in the conference program.

The Liver Meeting covers all aspects of liver disease, but a significant proportion of the nearly 2000 abstracts to be presented are devoted to treatment and management of patients with viral hepatitis.

Approximately 10% of Americans have some form of liver disease, according to the conference organizers. Liver cancer is one of the few cancers growing in incidence, and the ongoing obesity epidemic "has dire consequences for the nation's liver health and wellness."

Several pharmaceutical companies have already announced some of the new data to be presented on their experimental therapies:

Bristol-Myers Squibb: data on 4 compounds including approved anti-HBV drug entecavir (Baraclude), experimental HCV protease inhibitor BMS-650032, pegylated interferon lambda, and investigational compound brivanib for treatment of hepatocellular carcinoma.

GlobeImmune: late-breaker presentation on GI-5005 therapeutic HCV vaccine.

Idera Pharmaceuticals: data on DNA-based toll-like receptor 9 (TLR9) agonist IM0-2125 for HCV treatment.

Roche: data from a study of the experimental HCV protease inhibitor RG7227 (ITMN-191) plus an HCV polymerase inhibitor.

Schering-Plough: data on investigational HCV protease inhibitor boceprevir (including SPRINT-1 results) and next-generation HCV protease inhibitor narlaprevir (SCH 900518), as well as studies of pegylated interferon alfa-2b (PegIntron).

Scynexis: Phase 1b data on novel anti-HCV agent SCY-635.

Vertex: sustained virological response (SVR) data Study C208 and final PROVE-3 results on investigational HCV protease inhibitor telaprevir.

For further information about the Liver Meeting program, see www.aasld.org/thelivermeeting.

10/30/09

Sources

American Association for the Study of Liver Diseases.

Bristol-Myers Squibb. New Data on Four Bristol-Myers Squibb Compounds to Be Presented at AASLD 2009. Press release. October 1, 2009.

Bristol-Myers Squibb and ZymoGenetics. Bristol-Myers Squibb and ZymoGenetics to Present Final Phase Ib Data on PEG-Interferon Lambda at AASLD 2009. Press release. October 1, 2009.

GlobeImmune. GlobeImmune Announces Late-Breaker Presentation of GI-5005 Treatment Response Data at AASLD 2009 Meeting. Press release. October 6, 2009.

Schering-Plough . Schering-Plough Highlights Boceprevir, Narlaprevir (SCH 900518) and PegIntron Data at the American Association for the Study of Liver Diseases (AASLD) 2009 Annual Meeting. Press release. October 15, 2009.

Vertex. Vertex Pharmaceuticals Announces Publication of Telaprevir Abstracts for Presentation at the 60th AASLD Meeting. Press release. September 24, 2009.



 




 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

FDA-approved Combination Therapies for Chronic HCV Infection
Pegasys + Copegus
PEG-Intron + Rebetol
Intron A + Rebetol
Roferon A + Ribavirin


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